Viruses and bacteria in sputum samples of children with community-acquired pneumonia

June 22, 2011

Clinical Microbiology and Infections 20 June 2011

Maria Honkinen BM1, Elina Lahti MD1, Riikka ?sterback MSc2, Olli Ruuskanen MD1, Matti Waris PhD2

Abstract

Few comprehensive studies have searched for viruses and bacteria in children with community-acquired pneumonia (CAP). We identified 76 children hospitalized for pneumonia. Induced sputum samples were analysed for 18 viruses by antigen detection and polymerase chain reaction (PCR) and for 6 bacteria by culture and PCR. Viruses were found in 72%, bacteria in 91%, and both in 66%. Rhinovirus (30%), human bocavirus (18%), and human metapneumovirus (14%) were the most commonly detected viruses. Two viruses were found in 22% and three in 8%. The most common bacterial findings were Streptococcus pneumoniae (50%), Haemophilus influenzae (38%), and Moraxella catarrhalis (28%). Rhinovirus ?S. pneumoniae was the most commonly found combination of viruses and bacteria (16%). All 6 children with treatment failure had both viruses and bacteria detected in the sputum. Otherwise we found no special clinical characteristics in those with mixed viral-bacterial detections. With modern molecular diagnostic techniques, there are high rates of both viral and bacterial identifications in childhood CAP. The clinical significance of mixed viral-bacterial infections remains unclear though we found their potential association with a treatment failure.

abstract

http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2011.03603.x/abstract

Entry filed under: Bacterias, Infecciones respiratorias, Infecciones virales, Metodos diagnosticos. Tags: .

Source: http://infectonews.wordpress.com/2011/06/22/viruses-and-bacteria-in-sputum-samples-of-children-with-community-acquired-pneumonia

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